WP6 Patients

Description

Biological, technical and formal validation of results obtained from in vitro assays, is key for a proper understanding of the toxicological phenomena. To advance regulatory acceptance, molecular alterations and mechanistic insight derived from human cellular models need to be correlated with injury or potential for injury in humans. For this, it has been demonstrated that it is indeed feasible to integrate gene expression transcriptomics data from human cells with chemical and drug information together with disease information into what has been referred to as a “Connectivity Map”.