In analogy with Apollo Hekatos, the never-failing archer whose arrows always hit their target, the main goal of the HeCaToS project proposal is the establishment of a new integrative approach targeted towards highly predictive human safety assessment. We will generate a flexible prediction system, that can make an in silico prediction of xenobiotic metabolism, toxic liabilities and threshold doses with regard to liver and heart toxicity. This relates to the idea, expressed in a report by the European Partnership for Alternative Approaches to Animal Testing, entitled The Chemistry of Life: Revolutionizing Toxicology, that leading edge computational chemistry/ chemoinformatics and systems biology, when assembled in properly configured and validated computational systems, can revolutionize predictive toxicology and human safety assessment.

HeCaTos building blocks