Publications

• A Biophysical Systems Approach to Identifying the Pathways of Acute and Chronic Doxorubicin Mitochondrial Cardiotoxicity (4 Mb)
• A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations (8 Mb)
• A model‑based assay design to reproduce in vivo patterns of acute drug‑induced toxicity (515 kb)
• A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation (248 kb)
• Analyzing and interpreting genome data at the network level with ConsensusPathDB (6 Mb)
• iPSC-MSCs with High Intrinsic MIRO1 and Sensitivity to TNF-a Yield Efficacious Mitochondrial Transfer to Rescue Anthracycline-In (3 Mb)
• ARH-seq identification of differential splicing in RNA-seq data.pdf (247 kb)
• Cardio-Oncology: An update on Cardiotoxicity of Cancer-Related Treatment (3 Mb)
• Chemotherapy-Induced Cardiotoxicity: Detection, Prevention, and Management (588 kb)
• Development and Regulatory application of microRNA biomarkers (2 Mb)
• DTNI a novel toxicogenomics data analysis tool for identifying the molecular mechanisms underlying the adverse effects of toxic (336 kb)
• Estimating the Risk of Drug-Induced Proarrhythmia Using Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes (366 kb)
• FDA-approved drug labeling for the study of drug-induced liver injury (364 kb)
• Integration of genome-scale metabolic networks into wholebody PBPK models shows phenotype-specific cases of druginduced metaboli (3 Mb)
• Interlaboratory Reproducibility of a Targeted Metabolomics Platform for Analysis of Human Serum and Plasma (1 Mb)
• MEDIPS genome-wide differential coverage analysis of sequencing data derived from DNA enrichment experiments.pdf (233 kb)
• Multiscale Modeling Reveals Inhibitory and Stimulatory Effects of Caffeine on Acetaminophen-Induced Toxicity in Humans (1 Mb)
• Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity (370 kb)
• Predicting Regioselectivity and Lability of Cytochrome P450 Metabolism Using Quantum Mechanical Simulations (3 Mb)
• QSEA–modelling of genome-wide DNA methylation from sequencing enrichment experiments (3 Mb)
• Refining the Human iPSC-Cardiomyocyte Arrhythmic Risk Assessment Model (369 kb)
• Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxici (373 kb)
• The BioStudies database––one stop shop for all data supporting a life sciences study (1 Mb)
• The opportunities and challenges for biophysical modelling of beneficial and adverse drug actions on the heart (579 kb)
• Thesis-Matthias Lienhard-Computational Analysis of Genome-wide Methylation Enrichment Experiments (8 Mb)
• ToxDB: pathway-level interpretation of drug-treatment data (625 kb)
• Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations (3 Mb)
• WhichP450 a multi-class categorical model to predict the major metabolising CYP450 isoform for a compound (2 Mb)